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KMID : 0356919940270070838
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Korean Journal of Anesthesiology
1994 Volume.27 No. 7 p.838 ~ p.843
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Epidural Morphine-Bupivacaine versus Fentanyl-Bupivacaine for Postoperative pain control
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오지현
손향초/장진경/주진철
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Abstract
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The following study was performed in 100 patients undergoing gynecologic lower abdominal surgery. Analgesic efficacy, changes in arterial blood pressure and heart rate, and incidence of side effect were observed after epidural injection of the
drugs.
The patients were devided into two groups (N=50).
Group Ⅰwas given a bolus dose of 1 mg morphine in 10 ml of 0.25% bupivacaine followed by continuous epidural infusion of morphine 0.05 mg/ml in 0.15% bupivacaine at 2 ml/hr. Group Ⅱwas given a bolus dose of 100 ㎍fentanyl in 10ml of 0.25%
bupivacaine
followed by continuous epidural infusion of fentanyl 5㎍/ml in 0.15% bupivacaine at 2 ml/hr.
@ES The results were as follows.
@EN 1) The pain score (visual analogue pain scale) measured at postoperation 1 hr was significantly decreased in Group Ⅱ(1.51±1.0) compared to group Ⅰ(2.20±1.1). Percentage of patients needed supplemental analgesics within postoperation 20
min
was
significantly lower in Group Ⅱ(4%) than Group Ⅰ(16%).
2) the cardiovascular changes for 2 hrs after epidural injection were not occurred significant in both groups.
3) The incidence of nausea or vomiting was significantly lower in Group Ⅱ(8%) than Group Ⅰ(28%). Pruritus occurred also significantly less often in Group Ⅱ(6%) than group Ⅰ(305). Urinary retention and respiratory depression were not
observed.
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